Power of Nattokinase: Nature’s Enzyme for Optimal Health

What is Nattokinase?

Nattokinase is a potent natural enzyme derived from the traditional Japanese dish called natto, which is made from fermented soybeans. It is highly regarded for its ability to support various aspects of cardiovascular health and overall well-being.

Historical Background and Origins

The origins of nattokinase can be traced back to ancient Japan, where natto has been consumed for centuries due to its numerous health benefits.

It was initially discovered by a Japanese researcher named Dr. Hiroyuki Sumi in the 1980s and has since gained significant attention worldwide.

The Science behind Nattokinase’s Potential

Nattokinase’s potential lies in its unique ability to enhance fibrinolysis, the natural process by which the body breaks down blood clots.

It achieves this by directly dissolving fibrin, a protein involved in the formation of blood clots.

This remarkable enzymatic activity is what sets it apart and makes it a promising therapeutic agent.

Role in Fibrinolysis

Nattokinase plays a crucial role in the dissolution of blood clots by activating plasmin, an enzyme responsible for breaking down fibrin.

By promoting fibrinolysis, it helps maintain a healthy balance in the coagulation system and supports cardiovascular health.

Key Components and Structure of Nattokinase

Nattokinase is primarily composed of a single polypeptide chain with a molecular weight of approximately 28,000 Daltons.

Its unique structure gives it the ability to efficiently break down fibrin and prevent excessive blood clot formation.

How Nattokinase is Produced

To produce nattokinase, natto undergoes a fermentation process with the bacterium Bacillus subtilis.

This specific strain of bacteria is responsible for secreting the nattokinase enzyme, which is then extracted and purified for use in various forms, including dietary supplements.

Health Benefits of Nattokinase


Cardiovascular Health

  • Blood Pressure Regulation

It helps regulate blood pressure by promoting vasodilation, a process that widens the blood vessels and improves blood flow.

This effect may help you to maintain healthy blood pressure levels and reduce the risk of hypertension.

  • Cholesterol Management

Studies have demonstrated that nattokinase may aid in managing your cholesterol levels by promoting the breakdown of LDL (“bad”) cholesterol.

By improving cholesterol profile, it may contribute to a healthier cardiovascular system.

  • Preventing Blood Clots 

One of the most significant benefits of nattokinase is its ability to prevent the formation of blood clots.

By aiding in fibrinolysis, it can help you reduce the risk of clot-related conditions such as deep vein thrombosis, pulmonary embolism, and stroke.

Improved Circulation and Microvascular Health

  • Platelet Aggregation

Platelet aggregation, the clumping together of blood platelets, can contribute to the formation of clots.

Nattokinase has been shown to inhibit platelet aggregation, promoting smoother blood flow and preventing the formation of dangerous clots.

  • Enhanced Blood Flow and Capillary Health

By facilitating fibrin degradation and reducing the formation of microclots, it promotes better blood flow throughout the body, optimizing the delivery of oxygen and nutrients to all organs and tissues.

Moreover, nattokinase supports microvascular health, which plays a crucial role in maintaining overall well-being.

  • Varicose Veins and Edema

Varicose veins and edema are often caused by poor blood circulation and impaired lymphatic drainage.

Nattokinase’s ability to improve blood flow and reduce fibrinogen levels can be beneficial in alleviating these conditions.

Anti-Inflammatory Properties

  • Reduction of Inflammation Markers

Research suggests that nattokinase possesses potent anti-inflammatory properties, as it has been shown to decrease the levels of various inflammatory markers in the body.

By reducing inflammation, it may help protect against chronic diseases linked to inflammation.

  • Joint Health

Inflammation is a major contributor to joint pain and stiffness.

Its anti-inflammatory properties, combined with its ability to improve circulation and support microvascular health, may offer relief for individuals experiencing joint discomfort.

  • Alleviating Chronic Inflammatory Conditions

Preliminary studies indicate that nattokinase may hold potential in alleviating chronic inflammatory conditions, such as rheumatoid arthritis and inflammatory bowel disease.

Further research is needed to fully uncover the extent of its therapeutic benefits in these areas.

Potential Neuroprotective Effects 

  • Brain Health

Emerging evidence suggests that nattokinase may have neuroprotective effects, potentially aiding in the prevention of neurodegenerative diseases.

It is thought that its ability to improve blood flow and reduce inflammation could contribute to better brain health and function.

  • Cognitive Function

Some studies have indicated that it might have a positive impact on cognitive function and memory.

The improved blood flow and potential reduction in brain inflammation associated with it could support cognitive health, particularly in aging individuals.

  • Future Perspectives on Nattokinase and Neurodegeneration

While research on the neuroprotective effects of nattokinase is still in its early stages, the potential therapeutic applications of this enzyme in the field of neurodegeneration are promising.

Further studies are needed to explore its full range of benefits for brain health.

Nattokinase as a Complementary Therapeutic

  • Conventional Medical Approaches

It can be safely incorporated into existing treatment plans with appropriate medical supervision.

It is crucial to consult with a healthcare professional before initiating nattokinase supplementation, especially if you are currently taking blood-thinning medications or have underlying medical conditions.

  • Synergistic Effects with Other Natural Therapies

Nattokinase can be used synergistically with other natural therapies to enhance their effectiveness.

For example, combining it with omega-3 fatty acids or coenzyme Q10 may provide additional cardiovascular benefits.

Nattokinase for Sports Performance and Recovery

  • Importance of Blood Flow and Oxygenation for Athletes

Optimal blood flow and oxygenation are essential for peak athletic performance and efficient recovery.

Nattokinase’s ability to enhance circulation and support microvascular health may be beneficial for athletes looking to improve their endurance, stamina, and overall athletic performance.

  • Impact on Exercise-induced Muscle Damage

Intense exercise often leads to muscle damage and soreness.

Studies suggest that nattokinase might assist in reducing exercise-induced muscle damage and accelerating recovery, allowing athletes to bounce back faster and train more consistently.

Nattokinase’s Potential in Dermatology

  • Skin Health and Anti-aging

Nattokinase’s ability to promote healthy blood flow and microvascular function can also extend to the field of dermatology.

By improving circulation to the skin and supporting the delivery of essential nutrients and oxygen, it may contribute to vibrant, youthful-looking skin.

  • Addressing Skin Conditions 

Nattokinase’s anti-inflammatory properties may be beneficial in managing certain skin conditions characterized by inflammation, such as acne, eczema, and psoriasis.

Its potential to modulate the inflammatory response could offer a natural approach to skincare.

Safety, Dosage, and Potential Side Effects

Recommended Dosage and Administration

The appropriate dosage may vary depending on individual circumstances, and it is essential toBenefits of Nattokinase follow the manufacturer’s instructions or consult with a healthcare professional.

Typical dosages range from 100 to 2000 fibrinolysis units (FUs) per day, often divided into two doses for optimal absorption.

Potential Interactions and Contraindications

It may interact with certain medications, particularly anticoagulants and antiplatelet drugs.

It is crucial to inform your healthcare provider about any supplements you are taking to avoid potential interactions.

Additionally, individuals with bleeding disorders or undergoing surgery should exercise caution when considering nattokinase supplementation.

Adverse Reactions and Side Effects

It is generally considered safe and well-tolerated when consumed in appropriate amounts.

However, like any supplement, it may cause minor side effects such as digestive discomfort or allergic reactions in rare cases.

If any adverse reactions occur, discontinue use and consult a healthcare professional.

Incorporating Nattokinase into Your Lifestyle

Dietary Source 

It is primarily found in natto, a traditional Japanese dish made from fermented soybeans.

Incorporating natto into your diet is an excellent way to obtain natural nattokinase. However, its strong flavor and texture may not appeal to everyone.

Supplementation Options and Considerations

For those who cannot tolerate natto or are looking for a more convenient option, it is available in supplement form.

When choosing a nattokinase supplement, it is crucial to select a reputable brand that ensures quality, purity, and accurate dosing.

Precautions and Consultation with Healthcare Professionals

Before introducing this natural enxyme into your lifestyle, it is essential to consult with a healthcare professional, particularly if you have underlying health conditions or are currently taking medications.

They can provide personalized guidance on the appropriate dosage and potential interactions.

Nattokinase for Different Age Groups

Nattokinase holds potential benefits for individuals of all ages.

From supporting cardiovascular health in adults to promoting cognitive function in the elderly, it may be a valuable addition to a proactive wellness routine at any stage of life.

Research and Scientific Studies 

Prominent Research Findings

  • Clinical Trials

Numerous clinical trials have demonstrated the efficacy of nattokinase in various health contexts. These studies have investigated its potential in lowering blood pressure, improving cholesterol profiles, reducing blood clotting, and enhancing overall cardiovascular health.

  • Mechanistic Studies 

Mechanistic studies have shed light on the specific ways in which it acts on the body. Through understanding its interactions with fibrin, plasmin, and the coagulation system, researchers have delved into the precise mechanisms responsible for its therapeutic effects.

Ongoing Research and Future Directions

  • Exploring Novel Applications of Nattokinase

Ongoing research is expanding the scope of nattokinase’s potential applications. Scientists are studying its effects on conditions such as metabolic syndrome, obesity, inflammation-related diseases, and even cancer. These investigations aim to unlock its full therapeutic potential across various fields.

  • Areas for Further Investigation and Research

While its benefits are promising, further research is needed to elucidate its long-term safety, optimal dosages for specific health conditions, and potential interactions with medications. Continued scientific exploration will help refine our understanding of its role in overall health.

Frequently Asked Questions (FAQs)

What are the dietary sources of Nattokinase?

Nattokinase is primarily found in natto, a traditional Japanese dish made from fermented soybeans. It can be incorporated into various recipes or consumed as a standalone food.

Are there any potential side effects or interactions?

While it is generally safe, it may interact with medications, particularly anticoagulants and antiplatelet drugs. It is crucial to consult with a healthcare professional before taking nattokinase, especially if you have underlying health conditions or are on any medications.

Can Nattokinase replace blood-thinning medications?

It should not replace prescribed blood-thinning medications unless under the guidance of a healthcare professional. It can, however, be used as a complementary therapy alongside conventional treatments, potentially enhancing their effects.

Is Nattokinase suitable for vegetarians and vegans?

It is derived from fermented soybeans and is therefore suitable for vegetarians and vegans. However, it is essential to ensure that the nattokinase supplement is free from any animal-derived ingredients if you follow a strict plant-based diet.

How long does it take to experience the benefits ?

The timeframe to experience the benefits may vary from person to person. Some individuals may notice improvements in certain health markers within a few weeks, while others may require longer supplementation to observe noticeable changes. Consistency and adherence to the recommended dosage are key factors for optimal results.


Nattokinase, derived from the Japanese dish natto, offers a wide array of potential health benefits. From supporting cardiovascular health and improving circulation to reducing inflammation and promoting brain health, it can be a valuable addition to a comprehensive wellness routine.

When incorporating it into your lifestyle, it is crucial to follow recommended dosages and consult with a healthcare professional. It is essential to be aware of potential interactions with medications and to pay attention to any adverse reactions. Safety, efficacy, and personalized guidance should be prioritized.

Research continues to evolve, with ongoing studies investigating its potential in various health contexts and exploring novel applications. Future research will pave the way for a deeper understanding of its mechanisms and open up new avenues for using this powerful natural enzyme for optimal health.

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